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(TUSC1) tumor suppressor candidate 1 [Homo sapiens]

Gene

Transcript(s)

Exon(s)

Protein(s)

Gene

Accession	5151
Official symbol	TUSC1
Official name	tumor suppressor candidate 1
Gene type	gene with protein product
Organism	Homo sapiens
Location	Chromosome 9 (NC_000009.11) : 25676386...25678855 (-)
Map	9p21.2
Length	2470 nt

Alternative name(s) and Synynom(s)

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Synonyms	TSG9; MGC131751; TSG-9

External Links

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Ensembl	ENSG00000198680
Entrez	286319
HGNC	31010
HPRD	18247

Comment

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Summary	This gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis. It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines, suggesting that it may play a role in lung tumorigenesis. [provided by RefSeq].

Bibliography

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Related Articles in PubMed

Genomic Context

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Go to ensembl

Sequence

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	FASTA

1	TCTGTTTAAT	GTTTTATTAA	ACATAGGGGT	GGGTTAAACC	ACTGGGTTTT	AAATGAAGCA	CTTAGAGCTT	TTCAACTTGC
81	CCCATAGCTT	TGTCTCAGAA	CCGATCATTC	TATTATCATT	AGTTTTGAGA	ATGCCGTGTA	AAGAGCAAAG	TAACCACTGG
161	TGGTTGCACT	CCGGAGCGGG	CGAGGACGGC	TAGTTCCTGC	AGTGCCCAGG	CCTGCACGGA	AGCGCCCTGG	CACAACTCAG
241	CTGAGGATAC	ACGCTTTTTC	CCGCGCAGCC	GGAGGGCTGA	ACAGCAAAGC	ACTCCCCGGG	GGAACTGTGT	GTCAGCGCAG
321	CCTGGAGAGA	GCAGGCCCAG	GGGGCAGCTC	CACCACAGGA	GACAGGACAC	GCCTCAGTCT	GGGCAAATTC	CCGGCCTCCT
401	TTGGCTCTAA	GCCAGCAGCC	GCCGCCCGCG	ACCTCCTCTC	CTCCTCCGTC	GTCACCCCGG	CCGCCCTGCC	AGCCCCGAAC
481	TTGCCCGCGC	CTGGCCGCGC	GGCCCCTCAG	CCCACGGGGC	TGGCGGCGCG	GTTGGGATGG	GACCGATGTG	GCGCATGCGT
561	GGTGGCGCCA	CTAGGCGCGG	GAGTTGCTGC	GGCGGGGACG	GTGCTGCGGA	CGGCCGAGGG	CCAGGCCGCT	CCGGCCGGGC
641	TCGTGGTGGG	GGCAGCCCCA	GCGGCGGCGG	CGGCGGCGTG	GGCTGGCGAG	GCCGCGCGGA	CGGCGCCCGA	CAGCAGCTGG
721	AGGAGCGGTT	TGCCGACCTG	GCGGCGAGCC	ACTTGGAGGC	CATCCGTGCG	CGGGACGAGT	GGGACCGGCA	GAACGCGCGG
801	CTGCGTCAGG	AGAACGCCCG	GCTGCGGCTC	GAGAACCGGC	GGCTGAAGCG	CGAGAACCGC	AGCCTCTTCC	GTCAGGCTTT
881	GCGGCTCCCC	GGCGAAGGCG	GCAACGGGAC	GCCCGCGGAG	GCACGCCGGG	TCCCTGAAGA	GGCCAGCACG	AACCGGAGGG
961	CTAGAGACAG	CGGCCGAGAG	GACGAGCCGG	GCAGCCCCAG	GGCCCTGAGG	GCCCGACTTG	AGAAGCTGGA	AGCCATGTAC
1041	CGCCGGGCCC	TGCTGCAGCT	GCACCTCGAG	CAGCGGGGAC	CACGTCCGAG	CGGGGACAAG	GAGGAGCAGC	CTCTACAGGA
1121	ACCCGACTCC	GGCCTCCGCT	CCCGGGACTC	GGAGCCCTCT	GGGCCCTGGC	TGTAGCCGAG	GCCGCAGCCG	GTGAGAGGCG
1201	GAGCCTCGAG	CGGGCCCCTC	CTCCTCCGTT	CCCAGCTACC	CCCGACCTCG	CGCACGCCCT	GGCCCGCTCC	CTGCCCGCGG
1281	ATACCTTGGA	CTACGGTGCC	TTCCCGCCCC	CACCAGTGGA	CACTTCCGGG	TGGCGCTTGG	CCATCCGCTT	GGTGGAGGTC
1361	GAGTGGGTGC	AAGGGCCCTC	AGGACCTCCC	ACATGTACAG	TTCCCCTGCC	TCTTGCCCCG	GCTAGTTTCC	CTGGAGAGAG
1441	GCCTAGCCAA	CAACGAAGGG	ACGGATTTTA	AAACAGCGAG	AACTGGGTGC	CAAGAAACAC	TTCATATTCC	CTGAACTTTT
1521	CTGGATGTTG	TGCGAACCTG	TTGTATTTTT	TTTTTTCCTG	TATTTTGGTT	CTGAGGGATG	AGTAATGTGT	TTTTAGTTGG
1601	TTGAGTTTAT	CCATTCTTCA	ATCCCCTAAA	GCCTTCAGCT	ATTCTTTCAT	ATGTGGCCAA	CATTTTAAGT	ACAGTGTTTG
1681	CTTTTATAAG	TCGGTGTTAC	TTGGATGTCC	TATAAAATAC	CCACTTTTTA	TAAAGATGAT	ATTTATAACC	TAGGAACTCA
1761	TGCCTGTCTT	GGCTGCAGTC	CCTGTACATC	TAATATATAC	TGATTTGTTT	GCCCCCAGAG	AATTTTTAAG	GTATCTGCCT
1841	ATATCGTGAT	CTTTTGAAAT	GGTAAATAAA	TCTGGTGCAT	TAAAAATTAT	CTGAAAGGTT	GCGGCGAGTA	TTATTTGAAG
1921	TGTGTTACAT	TTTTATATTT	TTAAAAAGAT	ACCTTTATGA	ATATACTAAT	TTAAATCTGG	TTTTAGTTGT	CCTTAGTAAA
2001	CTATCATGTT	CTTTTAGCTT	CATGTAACAG	TGATCTTTTA	AAATAATCTA	AAGATTAGGT	AGTCTAAAAG	TTATTTTAAT
2081	CTTTAATGTT	CAATTAGCTT	AATTAGTACG	TAGATAATTT	GCCTTATTTT	GACTAAGGAC	TTTTAAGAAA	TTATAAATTA
2161	CTTGTATATC	AAAAGTTCCC	CTAACAAAGT	AATTTAAGTC	TCAGTTGTTA	TTTCAATGGC	ACAAAAAAGT	GACTAGTTTA
2241	GCAATAAATG	TCCTAAAATT	ACTTTTATTG	CGCTTCGTTA	ATAACACTTT	TGCCAACTAA	GTAATGAAGA	GGATACCATT
2321	GTGCCTGATA	AAAAAATCAT	AGGTCCAAGA	GTGTTTCAAT	GATGGAAAAC	ATTTCAGGGG	AAAAAATCAT	GAATAGAATT
2401	GTCAAGGGAA	TAAAATATAC	TAGTTATGGC	ATAGTCCAAA	AGTATTAAAT	ATTATATATT	ACAAAACAAT

	>ref\|Gene_ID:286319\|TUSC1\|NC_000009.11:25676386...25678855 (-) TCTGTTTAATGTTTTATTAAACATAGGGGTGGGTTAAACCACTGGGTTTTAAATGAAGCACTTAGAGCTTTTCAACTTGC CCCATAGCTTTGTCTCAGAACCGATCATTCTATTATCATTAGTTTTGAGAATGCCGTGTAAAGAGCAAAGTAACCACTGG TGGTTGCACTCCGGAGCGGGCGAGGACGGCTAGTTCCTGCAGTGCCCAGGCCTGCACGGAAGCGCCCTGGCACAACTCAG CTGAGGATACACGCTTTTTCCCGCGCAGCCGGAGGGCTGAACAGCAAAGCACTCCCCGGGGGAACTGTGTGTCAGCGCAG CCTGGAGAGAGCAGGCCCAGGGGGCAGCTCCACCACAGGAGACAGGACACGCCTCAGTCTGGGCAAATTCCCGGCCTCCT TTGGCTCTAAGCCAGCAGCCGCCGCCCGCGACCTCCTCTCCTCCTCCGTCGTCACCCCGGCCGCCCTGCCAGCCCCGAAC TTGCCCGCGCCTGGCCGCGCGGCCCCTCAGCCCACGGGGCTGGCGGCGCGGTTGGGATGGGACCGATGTGGCGCATGCGT GGTGGCGCCACTAGGCGCGGGAGTTGCTGCGGCGGGGACGGTGCTGCGGACGGCCGAGGGCCAGGCCGCTCCGGCCGGGC TCGTGGTGGGGGCAGCCCCAGCGGCGGCGGCGGCGGCGTGGGCTGGCGAGGCCGCGCGGACGGCGCCCGACAGCAGCTGG AGGAGCGGTTTGCCGACCTGGCGGCGAGCCACTTGGAGGCCATCCGTGCGCGGGACGAGTGGGACCGGCAGAACGCGCGG CTGCGTCAGGAGAACGCCCGGCTGCGGCTCGAGAACCGGCGGCTGAAGCGCGAGAACCGCAGCCTCTTCCGTCAGGCTTT GCGGCTCCCCGGCGAAGGCGGCAACGGGACGCCCGCGGAGGCACGCCGGGTCCCTGAAGAGGCCAGCACGAACCGGAGGG CTAGAGACAGCGGCCGAGAGGACGAGCCGGGCAGCCCCAGGGCCCTGAGGGCCCGACTTGAGAAGCTGGAAGCCATGTAC CGCCGGGCCCTGCTGCAGCTGCACCTCGAGCAGCGGGGACCACGTCCGAGCGGGGACAAGGAGGAGCAGCCTCTACAGGA ACCCGACTCCGGCCTCCGCTCCCGGGACTCGGAGCCCTCTGGGCCCTGGCTGTAGCCGAGGCCGCAGCCGGTGAGAGGCG GAGCCTCGAGCGGGCCCCTCCTCCTCCGTTCCCAGCTACCCCCGACCTCGCGCACGCCCTGGCCCGCTCCCTGCCCGCGG ATACCTTGGACTACGGTGCCTTCCCGCCCCCACCAGTGGACACTTCCGGGTGGCGCTTGGCCATCCGCTTGGTGGAGGTC GAGTGGGTGCAAGGGCCCTCAGGACCTCCCACATGTACAGTTCCCCTGCCTCTTGCCCCGGCTAGTTTCCCTGGAGAGAG GCCTAGCCAACAACGAAGGGACGGATTTTAAAACAGCGAGAACTGGGTGCCAAGAAACACTTCATATTCCCTGAACTTTT CTGGATGTTGTGCGAACCTGTTGTATTTTTTTTTTTCCTGTATTTTGGTTCTGAGGGATGAGTAATGTGTTTTTAGTTGG TTGAGTTTATCCATTCTTCAATCCCCTAAAGCCTTCAGCTATTCTTTCATATGTGGCCAACATTTTAAGTACAGTGTTTG CTTTTATAAGTCGGTGTTACTTGGATGTCCTATAAAATACCCACTTTTTATAAAGATGATATTTATAACCTAGGAACTCA TGCCTGTCTTGGCTGCAGTCCCTGTACATCTAATATATACTGATTTGTTTGCCCCCAGAGAATTTTTAAGGTATCTGCCT ATATCGTGATCTTTTGAAATGGTAAATAAATCTGGTGCATTAAAAATTATCTGAAAGGTTGCGGCGAGTATTATTTGAAG TGTGTTACATTTTTATATTTTTAAAAAGATACCTTTATGAATATACTAATTTAAATCTGGTTTTAGTTGTCCTTAGTAAA CTATCATGTTCTTTTAGCTTCATGTAACAGTGATCTTTTAAAATAATCTAAAGATTAGGTAGTCTAAAAGTTATTTTAAT CTTTAATGTTCAATTAGCTTAATTAGTACGTAGATAATTTGCCTTATTTTGACTAAGGACTTTTAAGAAATTATAAATTA CTTGTATATCAAAAGTTCCCCTAACAAAGTAATTTAAGTCTCAGTTGTTATTTCAATGGCACAAAAAAGTGACTAGTTTA GCAATAAATGTCCTAAAATTACTTTTATTGCGCTTCGTTAATAACACTTTTGCCAACTAAGTAATGAAGAGGATACCATT GTGCCTGATAAAAAAATCATAGGTCCAAGAGTGTTTCAATGATGGAAAACATTTCAGGGGAAAAAATCATGAATAGAATT GTCAAGGGAATAAAATATACTAGTTATGGCATAGTCCAAAAGTATTAAATATTATATATTACAAAACAAT

TUSC1, mRNA isoform 1 - Generality

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Primary source

RefSeq : NM_001004125.2 (GI:117306182)

Name

Tumor suppressor candidate 1 (TUSC1)

Type of transcript

mRNA

Organism

Homo sapiens

Length

2477 nt

Map

9p21.2

Location

Chromosome 9 (NC_000009.11) strand : -

25676386...25678855

Exon(s)

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Exon(s)	Start	End	Length	is coding
Exon 1	1	2470	2470	1

Variation(s)

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ID	Class	Location	Mutation	Length	is synonymous	Source
rs59975707	SNP	59	c/g	1	?	dbSNP
rs34772164	SNP	60	c/t	1	?	dbSNP
rs10967034	SNP	217	a/t	1	?	dbSNP
rs61483294	SNP	218	c/t	1	?	dbSNP
rs72631813	SNP	661	a/g	1	?	dbSNP
rs72631814	SNP	735	c/g	1	?	dbSNP
rs34498078	SNP	904	a/g	1	?	dbSNP
rs35110225	SNP	924	a/g	1	?	dbSNP
rs72631815	SNP	1159	g/t	1	?	dbSNP
rs10812300	SNP	1269	g/t	1	?	dbSNP
rs1128953	SNP	1508	g/t	1	?	dbSNP
rs1128957	SNP	1600	c/g	1	?	dbSNP
rs12348	SNP	1642	a/g	1	?	dbSNP
rs7028310	SNP	1902	c/g	1	?	dbSNP
rs7044566	SNP	1944	a/t	1	?	dbSNP
rs10812299	SNP	1962	a/g	1	?	dbSNP
rs10812298	SNP	2048	g/t	1	?	dbSNP
rs4592123	SNP	2273	g/t	1	?	dbSNP
rs73644561	SNP	2320	c/t	1	?	dbSNP
rs74174596	insertion	1547	-/t	1	?	dbSNP
rs35009436	insertion	1671	-/c	1	?	dbSNP
rs35346314	insertion	2110	-/t	1	?	dbSNP
rs58308104	insertion	2381	-/a	1	?	dbSNP

CDS

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Primary source

NCBI : CCDS34999

Nucleotide

TUSC1, mRNA isoform 1[NM_001004125.2] : 538...1176

Length

639

Location

Chromosome 9 (NC_000009.11) strand : -

25677680...25678318

Start codon

Translation

NP_001004125.1

Sequence

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	FASTA

1	TTCTGTTTAA	TGTTTTATTA	AACATAGGGG	TGGGTTAAAC	CACTGGGTTT	TAAATGAAGC	ACTTAGAGCT	TTTCAACTTG
81	CCCCATAGCT	TTGTCTCAGA	ACCGATCATT	CTATTATCAT	TAGTTTTGAG	AATGCCGTGT	AAAGAGCAAA	GTAACCACTG
161	GTGGTTGCAC	TCCGGAGCGG	GCGAGGACGG	CTAGTTCCTG	CAGTGCCCAG	GCCTGCACGG	AAGCGCCCTG	GCACAACTCA
241	GCTGAGGATA	CACGCTTTTT	CCCGCGCAGC	CGGAGGGCTG	AACAGCAAAG	CACTCCCCGG	GGGAACTGTG	TGTCAGCGCA
321	GCCTGGAGAG	AGCAGGCCCA	GGGGGCAGCT	CCACCACAGG	AGACAGGACA	CGCCTCAGTC	TGGGCAAATT	CCCGGCCTCC
401	TTTGGCTCTA	AGCCAGCAGC	CGCCGCCCGC	GACCTCCTCT	CCTCCTCCGT	CGTCACCCCG	GCCGCCCTGC	CAGCCCCGAA
481	CTTGCCCGCG	CCTGGCCGCG	CGGCCCCTCA	GCCCACGGGG	CTGGCGGCGC	GGTTGGGATG	GGACCGATGT	GGCGCATGCG
561	TGGTGGCGCC	ACTAGGCGCG	GGAGTTGCTG	CGGCGGGGAC	GGTGCTGCGG	ACGGCCGAGG	GCCAGGCCGC	TCCGGCCGGG
641	CTCGTGGTGG	GGGCAGCCCC	AGCGGCGGCG	GCGGCGGCGT	GGGCTGGCGA	GGCCGCGCGG	ACGGCGCCCG	ACAGCAGCTG
721	GAGGAGCGGT	TTGCCGACCT	GGCGGCGAGC	CACTTGGAGG	CCATCCGTGC	GCGGGACGAG	TGGGACCGGC	AGAACGCGCG
801	GCTGCGTCAG	GAGAACGCCC	GGCTGCGGCT	CGAGAACCGG	CGGCTGAAGC	GCGAGAACCG	CAGCCTCTTC	CGTCAGGCTT
881	TGCGGCTCCC	CGGCGAAGGC	GGCAACGGGA	CGCCCGCGGA	GGCACGCCGG	GTCCCTGAAG	AGGCCAGCAC	GAACCGGAGG
961	GCTAGAGACA	GCGGCCGAGA	GGACGAGCCG	GGCAGCCCCA	GGGCCCTGAG	GGCCCGACTT	GAGAAGCTGG	AAGCCATGTA
1041	CCGCCGGGCC	CTGCTGCAGC	TGCACCTCGA	GCAGCGGGGA	CCACGTCCGA	GCGGGGACAA	GGAGGAGCAG	CCTCTACAGG
1121	AACCCGACTC	CGGCCTCCGC	TCCCGGGACT	CGGAGCCCTC	TGGGCCCTGG	CTGTAGCCGA	GGCCGCAGCC	GGTGAGAGGC
1201	GGAGCCTCGA	GCGGGCCCCT	CCTCCTCCGT	TCCCAGCTAC	CCCCGACCTC	GCGCACGCCC	TGGCCCGCTC	CCTGCCCGCG
1281	GATACCTTGG	ACTACGGTGC	CTTCCCGCCC	CCACCAGTGG	ACACTTCCGG	GTGGCGCTTG	GCCATCCGCT	TGGTGGAGGT
1361	CGAGTGGGTG	CAAGGGCCCT	CAGGACCTCC	CACATGTACA	GTTCCCCTGC	CTCTTGCCCC	GGCTAGTTTC	CCTGGAGAGA
1441	GGCCTAGCCA	ACAACGAAGG	GACGGATTTT	AAAACAGCGA	GAACTGGGTG	CCAAGAAACA	CTTCATATTC	CCTGAACTTT
1521	TCTGGATGTT	GTGCGAACCT	GTTGTATTTT	TTTTTTTCCT	GTATTTTGGT	TCTGAGGGAT	GAGTAATGTG	TTTTTAGTTG
1601	GTTGAGTTTA	TCCATTCTTC	AATCCCCTAA	AGCCTTCAGC	TATTCTTTCA	TATGTGGCCA	ACATTTTAAG	TACAGTGTTT
1681	GCTTTTATAA	GTCGGTGTTA	CTTGGATGTC	CTATAAAATA	CCCACTTTTT	ATAAAGATGA	TATTTATAAC	CTAGGAACTC
1761	ATGCCTGTCT	TGGCTGCAGT	CCCTGTACAT	CTAATATATA	CTGATTTGTT	TGCCCCCAGA	GAATTTTTAA	GGTATCTGCC
1841	TATATCGTGA	TCTTTTGAAA	TGGTAAATAA	ATCTGGTGCA	TTAAAAATTA	TCTGAAAGGT	TGCGGCGAGT	ATTATTTGAA
1921	GTGTGTTACA	TTTTTATATT	TTTAAAAAGA	TACCTTTATG	AATATACTAA	TTTAAATCTG	GTTTTAGTTG	TCCTTAGTAA
2001	ACTATCATGT	TCTTTTAGCT	TCATGTAACA	GTGATCTTTT	AAAATAATCT	AAAGATTAGG	TAGTCTAAAA	GTTATTTTAA
2081	TCTTTAATGT	TCAATTAGCT	TAATTAGTAC	GTAGATAATT	TGCCTTATTT	TGACTAAGGA	CTTTTAAGAA	ATTATAAATT
2161	ACTTGTATAT	CAAAAGTTCC	CCTAACAAAG	TAATTTAAGT	CTCAGTTGTT	ATTTCAATGG	CACAAAAAAG	TGACTAGTTT
2241	AGCAATAAAT	GTCCTAAAAT	TACTTTTATT	GCGCTTCGTT	AATAACACTT	TTGCCAACTA	AGTAATGAAG	AGGATACCAT
2321	TGTGCCTGAT	AAAAAAATCA	TAGGTCCAAG	AGTGTTTCAA	TGATGGAAAA	CATTTCAGGG	GAAAAAATCA	TGAATAGAAT
2401	TGTCAAGGGA	ATAAAATATA	CTAGTTATGG	CATAGTCCAA	AAGTATTAAA	TATTATATAT	TACAAAACAA	AAAAAAA

	>gi\|117306182\|ref\|NM_001004125.2\|Tumor suppressor candidate 1 (TUSC1) TTCTGTTTAATGTTTTATTAAACATAGGGGTGGGTTAAACCACTGGGTTTTAAATGAAGCACTTAGAGCTTTTCAACTTG CCCCATAGCTTTGTCTCAGAACCGATCATTCTATTATCATTAGTTTTGAGAATGCCGTGTAAAGAGCAAAGTAACCACTG GTGGTTGCACTCCGGAGCGGGCGAGGACGGCTAGTTCCTGCAGTGCCCAGGCCTGCACGGAAGCGCCCTGGCACAACTCA GCTGAGGATACACGCTTTTTCCCGCGCAGCCGGAGGGCTGAACAGCAAAGCACTCCCCGGGGGAACTGTGTGTCAGCGCA GCCTGGAGAGAGCAGGCCCAGGGGGCAGCTCCACCACAGGAGACAGGACACGCCTCAGTCTGGGCAAATTCCCGGCCTCC TTTGGCTCTAAGCCAGCAGCCGCCGCCCGCGACCTCCTCTCCTCCTCCGTCGTCACCCCGGCCGCCCTGCCAGCCCCGAA CTTGCCCGCGCCTGGCCGCGCGGCCCCTCAGCCCACGGGGCTGGCGGCGCGGTTGGGATGGGACCGATGTGGCGCATGCG TGGTGGCGCCACTAGGCGCGGGAGTTGCTGCGGCGGGGACGGTGCTGCGGACGGCCGAGGGCCAGGCCGCTCCGGCCGGG CTCGTGGTGGGGGCAGCCCCAGCGGCGGCGGCGGCGGCGTGGGCTGGCGAGGCCGCGCGGACGGCGCCCGACAGCAGCTG GAGGAGCGGTTTGCCGACCTGGCGGCGAGCCACTTGGAGGCCATCCGTGCGCGGGACGAGTGGGACCGGCAGAACGCGCG GCTGCGTCAGGAGAACGCCCGGCTGCGGCTCGAGAACCGGCGGCTGAAGCGCGAGAACCGCAGCCTCTTCCGTCAGGCTT TGCGGCTCCCCGGCGAAGGCGGCAACGGGACGCCCGCGGAGGCACGCCGGGTCCCTGAAGAGGCCAGCACGAACCGGAGG GCTAGAGACAGCGGCCGAGAGGACGAGCCGGGCAGCCCCAGGGCCCTGAGGGCCCGACTTGAGAAGCTGGAAGCCATGTA CCGCCGGGCCCTGCTGCAGCTGCACCTCGAGCAGCGGGGACCACGTCCGAGCGGGGACAAGGAGGAGCAGCCTCTACAGG AACCCGACTCCGGCCTCCGCTCCCGGGACTCGGAGCCCTCTGGGCCCTGGCTGTAGCCGAGGCCGCAGCCGGTGAGAGGC GGAGCCTCGAGCGGGCCCCTCCTCCTCCGTTCCCAGCTACCCCCGACCTCGCGCACGCCCTGGCCCGCTCCCTGCCCGCG GATACCTTGGACTACGGTGCCTTCCCGCCCCCACCAGTGGACACTTCCGGGTGGCGCTTGGCCATCCGCTTGGTGGAGGT CGAGTGGGTGCAAGGGCCCTCAGGACCTCCCACATGTACAGTTCCCCTGCCTCTTGCCCCGGCTAGTTTCCCTGGAGAGA GGCCTAGCCAACAACGAAGGGACGGATTTTAAAACAGCGAGAACTGGGTGCCAAGAAACACTTCATATTCCCTGAACTTT TCTGGATGTTGTGCGAACCTGTTGTATTTTTTTTTTTCCTGTATTTTGGTTCTGAGGGATGAGTAATGTGTTTTTAGTTG GTTGAGTTTATCCATTCTTCAATCCCCTAAAGCCTTCAGCTATTCTTTCATATGTGGCCAACATTTTAAGTACAGTGTTT GCTTTTATAAGTCGGTGTTACTTGGATGTCCTATAAAATACCCACTTTTTATAAAGATGATATTTATAACCTAGGAACTC ATGCCTGTCTTGGCTGCAGTCCCTGTACATCTAATATATACTGATTTGTTTGCCCCCAGAGAATTTTTAAGGTATCTGCC TATATCGTGATCTTTTGAAATGGTAAATAAATCTGGTGCATTAAAAATTATCTGAAAGGTTGCGGCGAGTATTATTTGAA GTGTGTTACATTTTTATATTTTTAAAAAGATACCTTTATGAATATACTAATTTAAATCTGGTTTTAGTTGTCCTTAGTAA ACTATCATGTTCTTTTAGCTTCATGTAACAGTGATCTTTTAAAATAATCTAAAGATTAGGTAGTCTAAAAGTTATTTTAA TCTTTAATGTTCAATTAGCTTAATTAGTACGTAGATAATTTGCCTTATTTTGACTAAGGACTTTTAAGAAATTATAAATT ACTTGTATATCAAAAGTTCCCCTAACAAAGTAATTTAAGTCTCAGTTGTTATTTCAATGGCACAAAAAAGTGACTAGTTT AGCAATAAATGTCCTAAAATTACTTTTATTGCGCTTCGTTAATAACACTTTTGCCAACTAAGTAATGAAGAGGATACCAT TGTGCCTGATAAAAAAATCATAGGTCCAAGAGTGTTTCAATGATGGAAAACATTTCAGGGGAAAAAATCATGAATAGAAT TGTCAAGGGAATAAAATATACTAGTTATGGCATAGTCCAAAAGTATTAAATATTATATATTACAAAACAAAAAAAAA

TUSC1 - Exon 1

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Exon number	1
Length	2470 nt
Location	Chromosome 9 (NC_000009.11) : 25676386...25678855 (-)
Is part of	TUSC1, mRNA isoform 1 (NM_001004125.2)
Sequence	Show
	TTCTGTTTAATGTTTTATTAAACATAGGGGTGGGTTAAACCACTGGGTTTTAAATGAAGCACTTAGAGCTTTTCAACTTG CCCCATAGCTTTGTCTCAGAACCGATCATTCTATTATCATTAGTTTTGAGAATGCCGTGTAAAGAGCAAAGTAACCACTG GTGGTTGCACTCCGGAGCGGGCGAGGACGGCTAGTTCCTGCAGTGCCCAGGCCTGCACGGAAGCGCCCTGGCACAACTCA GCTGAGGATACACGCTTTTTCCCGCGCAGCCGGAGGGCTGAACAGCAAAGCACTCCCCGGGGGAACTGTGTGTCAGCGCA GCCTGGAGAGAGCAGGCCCAGGGGGCAGCTCCACCACAGGAGACAGGACACGCCTCAGTCTGGGCAAATTCCCGGCCTCC TTTGGCTCTAAGCCAGCAGCCGCCGCCCGCGACCTCCTCTCCTCCTCCGTCGTCACCCCGGCCGCCCTGCCAGCCCCGAA CTTGCCCGCGCCTGGCCGCGCGGCCCCTCAGCCCACGGGGCTGGCGGCGCGGTTGGGATGGGACCGATGTGGCGCATGCG TGGTGGCGCCACTAGGCGCGGGAGTTGCTGCGGCGGGGACGGTGCTGCGGACGGCCGAGGGCCAGGCCGCTCCGGCCGGG CTCGTGGTGGGGGCAGCCCCAGCGGCGGCGGCGGCGGCGTGGGCTGGCGAGGCCGCGCGGACGGCGCCCGACAGCAGCTG GAGGAGCGGTTTGCCGACCTGGCGGCGAGCCACTTGGAGGCCATCCGTGCGCGGGACGAGTGGGACCGGCAGAACGCGCG GCTGCGTCAGGAGAACGCCCGGCTGCGGCTCGAGAACCGGCGGCTGAAGCGCGAGAACCGCAGCCTCTTCCGTCAGGCTT TGCGGCTCCCCGGCGAAGGCGGCAACGGGACGCCCGCGGAGGCACGCCGGGTCCCTGAAGAGGCCAGCACGAACCGGAGG GCTAGAGACAGCGGCCGAGAGGACGAGCCGGGCAGCCCCAGGGCCCTGAGGGCCCGACTTGAGAAGCTGGAAGCCATGTA CCGCCGGGCCCTGCTGCAGCTGCACCTCGAGCAGCGGGGACCACGTCCGAGCGGGGACAAGGAGGAGCAGCCTCTACAGG AACCCGACTCCGGCCTCCGCTCCCGGGACTCGGAGCCCTCTGGGCCCTGGCTGTAGCCGAGGCCGCAGCCGGTGAGAGGC GGAGCCTCGAGCGGGCCCCTCCTCCTCCGTTCCCAGCTACCCCCGACCTCGCGCACGCCCTGGCCCGCTCCCTGCCCGCG GATACCTTGGACTACGGTGCCTTCCCGCCCCCACCAGTGGACACTTCCGGGTGGCGCTTGGCCATCCGCTTGGTGGAGGT CGAGTGGGTGCAAGGGCCCTCAGGACCTCCCACATGTACAGTTCCCCTGCCTCTTGCCCCGGCTAGTTTCCCTGGAGAGA GGCCTAGCCAACAACGAAGGGACGGATTTTAAAACAGCGAGAACTGGGTGCCAAGAAACACTTCATATTCCCTGAACTTT TCTGGATGTTGTGCGAACCTGTTGTATTTTTTTTTTTCCTGTATTTTGGTTCTGAGGGATGAGTAATGTGTTTTTAGTTG GTTGAGTTTATCCATTCTTCAATCCCCTAAAGCCTTCAGCTATTCTTTCATATGTGGCCAACATTTTAAGTACAGTGTTT GCTTTTATAAGTCGGTGTTACTTGGATGTCCTATAAAATACCCACTTTTTATAAAGATGATATTTATAACCTAGGAACTC ATGCCTGTCTTGGCTGCAGTCCCTGTACATCTAATATATACTGATTTGTTTGCCCCCAGAGAATTTTTAAGGTATCTGCC TATATCGTGATCTTTTGAAATGGTAAATAAATCTGGTGCATTAAAAATTATCTGAAAGGTTGCGGCGAGTATTATTTGAA GTGTGTTACATTTTTATATTTTTAAAAAGATACCTTTATGAATATACTAATTTAAATCTGGTTTTAGTTGTCCTTAGTAA ACTATCATGTTCTTTTAGCTTCATGTAACAGTGATCTTTTAAAATAATCTAAAGATTAGGTAGTCTAAAAGTTATTTTAA TCTTTAATGTTCAATTAGCTTAATTAGTACGTAGATAATTTGCCTTATTTTGACTAAGGACTTTTAAGAAATTATAAATT ACTTGTATATCAAAAGTTCCCCTAACAAAGTAATTTAAGTCTCAGTTGTTATTTCAATGGCACAAAAAAGTGACTAGTTT AGCAATAAATGTCCTAAAATTACTTTTATTGCGCTTCGTTAATAACACTTTTGCCAACTAAGTAATGAAGAGGATACCAT TGTGCCTGATAAAAAAATCATAGGTCCAAGAGTGTTTCAATGATGGAAAACATTTCAGGGGAAAAAATCATGAATAGAAT TGTCAAGGGAATAAAATATACTAGTTATGGCATAGTCCAAAAGTATTAAATATTATATATTACAAAACAA

Q2TAM9 - Generality

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Primary source	Uniprot : Q2TAM9
Name	Tumor suppressor candidate gene 1 protein
Alternative name(s)	TSG-9
Synonym(s)	TSG9
Organism	Homo sapiens
Length	212 aa
Protein existence	---

External Links

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ArrayExpress	Q2TAM9
Refseq	NP_001004125.1
Uniprot	Q2TAM9
KEGG	hsa:286319

General annotation (Comments)

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Tissue specificity	Widely expressed at low level. Expressed at higher level in testis, weakly expressed in muscle, colon, lung and spleen. Not detected in 3 non small cell lung carcinoma (NSCLC) cell lines with homozygous deletion of the 9p region, while it is down-regulated in 3 other tumor cell lines.

Ontologies

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Binary interactions

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With	Uniprot accession	IntAct

Alternative product(s)

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Sequence annotation

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Feature key	Position	Length	Description	Feature identifier
Region
Coiled coil	73 - 117	45	Potential	Q2TAM9-COILED-73
Coiled coil	155 - 180	26	Potential	Q2TAM9-COILED-155
Compositional bias	9 - 56	48	Gly-rich	Q2TAM9-COMPBIAS-9
Natural variations
Natural variant site	123 - 123	1	N -> D (in dbSNP:rs34498078)	VAR_037471
Amino acid modifications
Modified residue	145 - 145	1	Phosphoserine	Q2TAM9-MOD_RES-145
Modified residue	153 - 153	1	Phosphoserine	Q2TAM9-MOD_RES-153

Sequence

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	FASTA

1	MGPMWRMRGG	ATRRGSCCGG	DGAADGRGPG	RSGRARGGGS	PSGGGGGVGW	RGRADGARQQ	LEERFADLAA	SHLEAIRARD
81	EWDRQNARLR	QENARLRLEN	RRLKRENRSL	FRQALRLPGE	GGNGTPAEAR	RVPEEASTNR	RARDSGREDE	PGSPRALRAR
161	LEKLEAMYRR	ALLQLHLEQR	GPRPSGDKEE	QPLQEPDSGL	RSRDSEPSGP	WL