| (FOS) FBJ murine osteosarcoma viral oncogene homolog [Homo sapiens] |
|
|
|
|
|
|
|
|
Gene
Transcript(s)
Exon(s)
Protein(s)
|
|
|
Accession
|
7654
|
|
Official symbol
|
FOS
|
|
Official name
|
FBJ murine osteosarcoma viral oncogene homolog
|
|
Gene type
|
gene with protein product
|
|
Organism
|
Homo sapiens
|
|
Location
|
Chromosome 14 (NC_000014.8) : 75745530...75748912 (+)
|
|
Map
|
14q24.3
|
|
Length
|
3383 nt
|
|
NM_005252.2
|
FOS, mRNA isoform 1
|
|
Accession
|
Name
|
Organism
|
Length
|
|
P01100
|
Proto-oncogene c-Fos
|
Homo sapiens
|
380 aa
|
|
Q6FG41
|
FOS protein [submitted name]
|
Homo sapiens
|
380 aa
|
| |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Synonyms |
c-fos; AP-1
|
| Alternative name(s) |
activator protein 1; cellular oncogene c-fos; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS); v-fos FBJ murine osteosarcoma viral oncogene homolog
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Summary |
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq].
|
|
|
|
|
|
|
|
|
|
|
|
|
Related Articles in PubMed
|
|
|
|
|
|
|
|
|
|
|
|
Go to ensembl 
|
|
|
|
|
|
|
|
|
|
|
|
| 1 |
CAACCGCATC |
TGCAGCGAGC |
ATCTGAGAAG |
CCAAGACTGA |
GCCGGCGGCC |
GCGGCGCAGC |
GAACGAGCAG |
TGACCGTGCT |
|
| 81 |
CCTACCCAGC |
TCTGCTCCAC |
AGCGCCCACC |
TGTCTCCGCC |
CCTCGGCCCC |
TCGCCCGGCT |
TTGCCTAACC |
GCCACGATGA |
|
| 161 |
TGTTCTCGGG |
CTTCAACGCA |
GACTACGAGG |
CGTCATCCTC |
CCGCTGCAGC |
AGCGCGTCCC |
CGGCCGGGGA |
TAGCCTCTCT |
|
| 241 |
TACTACCACT |
CACCCGCAGA |
CTCCTTCTCC |
AGCATGGGCT |
CGCCTGTCAA |
CGCGCAGGTA |
AGGCTGGCTT |
CCCGTCGCCG |
|
| 321 |
CGGGGCCGGG |
GGCTTGGGGT |
CGCGGAGGAG |
GAGACACCGG |
GCGGGACGCT |
CCAGTAGATG |
AGTAGGGGGC |
TCCCTTGTGC |
|
| 401 |
CTGGAGGGAG |
GCTGCCGTGG |
CCGGAGCGGT |
GCCGGCTCGG |
GGGCTCGGGA |
CTTGCTCTGA |
GCGCACGCAC |
GCTTGCCATA |
|
| 481 |
GTAAGAATTG |
GTTCCCCCTT |
CGGGAGGCAG |
GTTCGTTCTG |
AGCAACCTCT |
GGTCTGCACT |
CCAGGACGGA |
TCTCTGACAT |
|
| 561 |
TAGCTGGAGC |
AGACGTGTCC |
CAAGCACAAA |
CTCGCTAACT |
AGAGCCTGGC |
TTCTCCGGGG |
AGGTGGCAGA |
AAGCGGCAAT |
|
| 641 |
CCCCCCTCCC |
CCGGCAGCCT |
GGAGCACGGA |
GGAGGGATGA |
GGGAGGAGGG |
TGCAGCGGGC |
GGGTGTGTAA |
GGCAGTTTCA |
|
| 721 |
TTGATAAAAA |
GCGAGTTCAT |
TCTGGAGACT |
CCGGAGCGGC |
GCCTGCGTCA |
GCGCAGACGT |
CAGGGATATT |
TATAACAAAC |
|
| 801 |
CCCCTTTCAA |
GCAAGTGATG |
CTGAAGGGAT |
AACGGGAACG |
CAGCGGCAGG |
ATGGAAGAGA |
CAGGCACTGC |
GCTGCGGAAT |
|
| 881 |
GCCTGGGAGG |
AAAAGGGGGA |
GACCTTTCAT |
CCAGGATGAG |
GGACATTTAA |
GATGAAATGT |
CCGTGGCAGG |
ATCGTTTCTC |
|
| 961 |
TTCACTGCTG |
CATGCGGCAC |
TGGGAACTCG |
CCCCACCTGT |
GTCCGGAACC |
TGCTCGCTCA |
CGTCGGCTTT |
CCCCTTCTGT |
|
| 1041 |
TTTGTTCTAG |
GACTTCTGCA |
CGGACCTGGC |
CGTCTCCAGT |
GCCAACTTCA |
TTCCCACGGT |
CACTGCCATC |
TCGACCAGTC |
|
| 1121 |
CGGACCTGCA |
GTGGCTGGTG |
CAGCCCGCCC |
TCGTCTCCTC |
CGTGGCCCCA |
TCGCAGACCA |
GAGCCCCTCA |
CCCTTTCGGA |
|
| 1201 |
GTCCCCGCCC |
CCTCCGCTGG |
GGCTTACTCC |
AGGGCTGGCG |
TTGTGAAGAC |
CATGACAGGA |
GGCCGAGCGC |
AGAGCATTGG |
|
| 1281 |
CAGGAGGGGC |
AAGGTGGAAC |
AGGTGAGGAA |
CTCTAGCGTA |
CTCTTCCTGG |
GAATGTGGGG |
GCTGGGTGGG |
AAGCAGCCCC |
|
| 1361 |
GGAGATGCAG |
GAGCCCAGTA |
CAGAGGATGA |
AGCCACTGAT |
GGGGCTGGCT |
GCACATCCGT |
AACTGGGAGC |
CCTGGCTCCA |
|
| 1441 |
AGCCCATTCC |
ATCCCAACTC |
AGACTCTGAG |
TCTCACCCTA |
AGAAGTACTC |
TCATAGTTTC |
TTCCCTAAGT |
TTCTTACCGC |
|
| 1521 |
ATGCTTTCAG |
ACTGGGCTCT |
TCTTTGTTCT |
CTTGCTGAGG |
ATCTTATTTT |
AAATGCAAGT |
CACACCTAGT |
CTGCAACTGC |
|
| 1601 |
AGGTCAGAAA |
TGGTTTCACA |
GTGGGGTGCC |
AGGAAGCAGG |
GAAGCTGCAG |
GAGCCAGTTC |
TACTGGGGTG |
GGTGAATGGA |
|
| 1681 |
GGTGATGGCA |
GACACTTTTA |
CTGAATGTCG |
GTCTTTTTTT |
GTGATTATTC |
TAGTTATCTC |
CAGAAGAAGA |
AGAGAAAAGG |
|
| 1761 |
AGAATCCGAA |
GGGAAAGGAA |
TAAGATGGCT |
GCAGCCAAAT |
GCCGCAACCG |
GAGGAGGGAG |
CTGACTGATA |
CACTCCAAGC |
|
| 1841 |
GGTAGGTACT |
CTGTGGGTTG |
CTCCTTTTTA |
AAACTTAAGG |
GGAAAGTTGG |
AGATTGAGCA |
TAAGGGCCCT |
TGAGTAAGAC |
|
| 1921 |
TGTGTCTTAT |
GCTTTCCTTT |
ATCCCTCTGT |
ATACAGGAGA |
CAGACCAACT |
AGAAGATGAG |
AAGTCTGCTT |
TGCAGACCGA |
|
| 2001 |
GATTGCCAAC |
CTGCTGAAGG |
AGAAGGAAAA |
ACTAGAGTTC |
ATCCTGGCAG |
CTCACCGACC |
TGCCTGCAAG |
ATCCCTGATG |
|
| 2081 |
ACCTGGGCTT |
CCCAGAAGAG |
ATGTCTGTGG |
CTTCCCTTGA |
TCTGACTGGG |
GGCCTGCCAG |
AGGTTGCCAC |
CCCGGAGTCT |
|
| 2161 |
GAGGAGGCCT |
TCACCCTGCC |
TCTCCTCAAT |
GACCCTGAGC |
CCAAGCCCTC |
AGTGGAACCT |
GTCAAGAGCA |
TCAGCAGCAT |
|
| 2241 |
GGAGCTGAAG |
ACCGAGCCCT |
TTGATGACTT |
CCTGTTCCCA |
GCATCATCCA |
GGCCCAGTGG |
CTCTGAGACA |
GCCCGCTCCG |
|
| 2321 |
TGCCAGACAT |
GGACCTATCT |
GGGTCCTTCT |
ATGCAGCAGA |
CTGGGAGCCT |
CTGCACAGTG |
GCTCCCTGGG |
GATGGGGCCC |
|
| 2401 |
ATGGCCACAG |
AGCTGGAGCC |
CCTGTGCACT |
CCGGTGGTCA |
CCTGTACTCC |
CAGCTGCACT |
GCTTACACGT |
CTTCCTTCGT |
|
| 2481 |
CTTCACCTAC |
CCCGAGGCTG |
ACTCCTTCCC |
CAGCTGTGCA |
GCTGCCCACC |
GCAAGGGCAG |
CAGCAGCAAT |
GAGCCTTCCT |
|
| 2561 |
CTGACTCGCT |
CAGCTCACCC |
ACGCTGCTGG |
CCCTGTGAGG |
GGGCAGGGAA |
GGGGAGGCAG |
CCGGCACCCA |
CAAGTGCCAC |
|
| 2641 |
TGCCCGAGCT |
GGTGCATTAC |
AGAGAGGAGA |
AACACATCTT |
CCCTAGAGGG |
TTCCTGTAGA |
CCTAGGGAGG |
ACCTTATCTG |
|
| 2721 |
TGCGTGAAAC |
ACACCAGGCT |
GTGGGCCTCA |
AGGACTTGAA |
AGCATCCATG |
TGTGGACTCA |
AGTCCTTACC |
TCTTCCGGAG |
|
| 2801 |
ATGTAGCAAA |
ACGCATGGAG |
TGTGTATTGT |
TCCCAGTGAC |
ACTTCAGAGA |
GCTGGTAGTT |
AGTAGCATGT |
TGAGCCAGGC |
|
| 2881 |
CTGGGTCTGT |
GTCTCTTTTC |
TCTTTCTCCT |
TAGTCTTCTC |
ATAGCATTAA |
CTAATCTATT |
GGGTTCATTA |
TTGGAATTAA |
|
| 2961 |
CCTGGTGCTG |
GATATTTTCA |
AATTGTATCT |
AGTGCAGCTG |
ATTTTAACAA |
TAACTACTGT |
GTTCCTGGCA |
ATAGTGTGTT |
|
| 3041 |
CTGATTAGAA |
ATGACCAATA |
TTATACTAAG |
AAAAGATACG |
ACTTTATTTT |
CTGGTAGATA |
GAAATAAATA |
GCTATATCCA |
|
| 3121 |
TGTACTGTAG |
TTTTTCTTCA |
ACATCAATGT |
TCATTGTAAT |
GTTACTGATC |
ATGCATTGTT |
GAGGTGGTCT |
GAATGTTCTG |
|
| 3201 |
ACATTAACAG |
TTTTCCATGA |
AAACGTTTTA |
TTGTGTTTTT |
AATTTATTTA |
TTAAGATGGA |
TTCTCAGATA |
TTTATATTTT |
|
| 3281 |
TATTTTATTT |
TTTTCTACCT |
TGAGGTCTTT |
TGACATGTGG |
AAAGTGAATT |
TGAATGAAAA |
ATTTAAGCAT |
TGTTTGCTTA |
|
| 3361 |
TTGTTCCAAG |
ACATTGTCAA |
TAA |
|
|
|
|
|
|
|
|
|
|
|
|
>ref|Gene_ID:2353|FOS|NC_000014.8:75745530...75748912 (+)
CAACCGCATCTGCAGCGAGCATCTGAGAAGCCAAGACTGAGCCGGCGGCCGCGGCGCAGCGAACGAGCAGTGACCGTGCT
CCTACCCAGCTCTGCTCCACAGCGCCCACCTGTCTCCGCCCCTCGGCCCCTCGCCCGGCTTTGCCTAACCGCCACGATGA
TGTTCTCGGGCTTCAACGCAGACTACGAGGCGTCATCCTCCCGCTGCAGCAGCGCGTCCCCGGCCGGGGATAGCCTCTCT
TACTACCACTCACCCGCAGACTCCTTCTCCAGCATGGGCTCGCCTGTCAACGCGCAGGTAAGGCTGGCTTCCCGTCGCCG
CGGGGCCGGGGGCTTGGGGTCGCGGAGGAGGAGACACCGGGCGGGACGCTCCAGTAGATGAGTAGGGGGCTCCCTTGTGC
CTGGAGGGAGGCTGCCGTGGCCGGAGCGGTGCCGGCTCGGGGGCTCGGGACTTGCTCTGAGCGCACGCACGCTTGCCATA
GTAAGAATTGGTTCCCCCTTCGGGAGGCAGGTTCGTTCTGAGCAACCTCTGGTCTGCACTCCAGGACGGATCTCTGACAT
TAGCTGGAGCAGACGTGTCCCAAGCACAAACTCGCTAACTAGAGCCTGGCTTCTCCGGGGAGGTGGCAGAAAGCGGCAAT
CCCCCCTCCCCCGGCAGCCTGGAGCACGGAGGAGGGATGAGGGAGGAGGGTGCAGCGGGCGGGTGTGTAAGGCAGTTTCA
TTGATAAAAAGCGAGTTCATTCTGGAGACTCCGGAGCGGCGCCTGCGTCAGCGCAGACGTCAGGGATATTTATAACAAAC
CCCCTTTCAAGCAAGTGATGCTGAAGGGATAACGGGAACGCAGCGGCAGGATGGAAGAGACAGGCACTGCGCTGCGGAAT
GCCTGGGAGGAAAAGGGGGAGACCTTTCATCCAGGATGAGGGACATTTAAGATGAAATGTCCGTGGCAGGATCGTTTCTC
TTCACTGCTGCATGCGGCACTGGGAACTCGCCCCACCTGTGTCCGGAACCTGCTCGCTCACGTCGGCTTTCCCCTTCTGT
TTTGTTCTAGGACTTCTGCACGGACCTGGCCGTCTCCAGTGCCAACTTCATTCCCACGGTCACTGCCATCTCGACCAGTC
CGGACCTGCAGTGGCTGGTGCAGCCCGCCCTCGTCTCCTCCGTGGCCCCATCGCAGACCAGAGCCCCTCACCCTTTCGGA
GTCCCCGCCCCCTCCGCTGGGGCTTACTCCAGGGCTGGCGTTGTGAAGACCATGACAGGAGGCCGAGCGCAGAGCATTGG
CAGGAGGGGCAAGGTGGAACAGGTGAGGAACTCTAGCGTACTCTTCCTGGGAATGTGGGGGCTGGGTGGGAAGCAGCCCC
GGAGATGCAGGAGCCCAGTACAGAGGATGAAGCCACTGATGGGGCTGGCTGCACATCCGTAACTGGGAGCCCTGGCTCCA
AGCCCATTCCATCCCAACTCAGACTCTGAGTCTCACCCTAAGAAGTACTCTCATAGTTTCTTCCCTAAGTTTCTTACCGC
ATGCTTTCAGACTGGGCTCTTCTTTGTTCTCTTGCTGAGGATCTTATTTTAAATGCAAGTCACACCTAGTCTGCAACTGC
AGGTCAGAAATGGTTTCACAGTGGGGTGCCAGGAAGCAGGGAAGCTGCAGGAGCCAGTTCTACTGGGGTGGGTGAATGGA
GGTGATGGCAGACACTTTTACTGAATGTCGGTCTTTTTTTGTGATTATTCTAGTTATCTCCAGAAGAAGAAGAGAAAAGG
AGAATCCGAAGGGAAAGGAATAAGATGGCTGCAGCCAAATGCCGCAACCGGAGGAGGGAGCTGACTGATACACTCCAAGC
GGTAGGTACTCTGTGGGTTGCTCCTTTTTAAAACTTAAGGGGAAAGTTGGAGATTGAGCATAAGGGCCCTTGAGTAAGAC
TGTGTCTTATGCTTTCCTTTATCCCTCTGTATACAGGAGACAGACCAACTAGAAGATGAGAAGTCTGCTTTGCAGACCGA
GATTGCCAACCTGCTGAAGGAGAAGGAAAAACTAGAGTTCATCCTGGCAGCTCACCGACCTGCCTGCAAGATCCCTGATG
ACCTGGGCTTCCCAGAAGAGATGTCTGTGGCTTCCCTTGATCTGACTGGGGGCCTGCCAGAGGTTGCCACCCCGGAGTCT
GAGGAGGCCTTCACCCTGCCTCTCCTCAATGACCCTGAGCCCAAGCCCTCAGTGGAACCTGTCAAGAGCATCAGCAGCAT
GGAGCTGAAGACCGAGCCCTTTGATGACTTCCTGTTCCCAGCATCATCCAGGCCCAGTGGCTCTGAGACAGCCCGCTCCG
TGCCAGACATGGACCTATCTGGGTCCTTCTATGCAGCAGACTGGGAGCCTCTGCACAGTGGCTCCCTGGGGATGGGGCCC
ATGGCCACAGAGCTGGAGCCCCTGTGCACTCCGGTGGTCACCTGTACTCCCAGCTGCACTGCTTACACGTCTTCCTTCGT
CTTCACCTACCCCGAGGCTGACTCCTTCCCCAGCTGTGCAGCTGCCCACCGCAAGGGCAGCAGCAGCAATGAGCCTTCCT
CTGACTCGCTCAGCTCACCCACGCTGCTGGCCCTGTGAGGGGGCAGGGAAGGGGAGGCAGCCGGCACCCACAAGTGCCAC
TGCCCGAGCTGGTGCATTACAGAGAGGAGAAACACATCTTCCCTAGAGGGTTCCTGTAGACCTAGGGAGGACCTTATCTG
TGCGTGAAACACACCAGGCTGTGGGCCTCAAGGACTTGAAAGCATCCATGTGTGGACTCAAGTCCTTACCTCTTCCGGAG
ATGTAGCAAAACGCATGGAGTGTGTATTGTTCCCAGTGACACTTCAGAGAGCTGGTAGTTAGTAGCATGTTGAGCCAGGC
CTGGGTCTGTGTCTCTTTTCTCTTTCTCCTTAGTCTTCTCATAGCATTAACTAATCTATTGGGTTCATTATTGGAATTAA
CCTGGTGCTGGATATTTTCAAATTGTATCTAGTGCAGCTGATTTTAACAATAACTACTGTGTTCCTGGCAATAGTGTGTT
CTGATTAGAAATGACCAATATTATACTAAGAAAAGATACGACTTTATTTTCTGGTAGATAGAAATAAATAGCTATATCCA
TGTACTGTAGTTTTTCTTCAACATCAATGTTCATTGTAATGTTACTGATCATGCATTGTTGAGGTGGTCTGAATGTTCTG
ACATTAACAGTTTTCCATGAAAACGTTTTATTGTGTTTTTAATTTATTTATTAAGATGGATTCTCAGATATTTATATTTT
TATTTTATTTTTTTCTACCTTGAGGTCTTTTGACATGTGGAAAGTGAATTTGAATGAAAAATTTAAGCATTGTTTGCTTA
TTGTTCCAAGACATTGTCAATAA
|
|
|
| |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Primary source |
RefSeq : NM_005252.2 (GI:6552332)
|
| Name |
V-fos FBJ murine osteosarcoma viral oncogene homolog (FOS)
|
| Type of transcript |
mRNA
|
| Organism |
Homo sapiens
|
| Length |
2084 nt
|
| Map |
14q24.3
|
| Location |
Chromosome 14 (NC_000014.8) strand : +
| 75745530...75745825 | 75746579...75746830 | 75747262...75747369 | 75747485...75748912 |
|
|
|
|
|
|
|
|
|
|
|
|
|
| Exon(s) |
Start |
End |
Length |
is coding |
|
Exon 1
|
1
|
296
|
296
|
1
|
|
Exon 2
|
297
|
548
|
252
|
1
|
|
Exon 3
|
549
|
656
|
108
|
1
|
|
Exon 4
|
657
|
2084
|
1428
|
1
|
|
|
|
|
|
|
|
|
|
|
|
|
| ID |
Class |
Location |
Mutation |
Length |
is synonymous |
Source |
|
|
|
|
|
|
|
|
|
|
|
|
| Primary source |
NCBI : CCDS9841
|
| Nucleotide |
FOS, mRNA isoform 1[NM_005252.2] : 156...1298
|
| Length |
1143
|
| Location |
Chromosome 14 (NC_000014.8) strand : +
| 75745685...75745825 | 75746579...75746830 | 75747262...75747369 | 75747485...75748126 |
|
| Start codon |
1
|
| Translation |
NP_005243.1 |
|
|
|
|
|
|
|
|
|
|
|
|
| 1 |
AACCGCATCT |
GCAGCGAGCA |
ACTGAGAAGC |
CAAGACTGAG |
CCGGCGGCCG |
CGGCGCAGCG |
AACGAGCAGT |
GACCGTGCTC |
|
| 81 |
CTACCCAGCT |
CTGCTTCACA |
GCGCCCACCT |
GTCTCCGCCC |
CTCGGCCCCT |
CGCCCGGCTT |
TGCCTAACCG |
CCACGATGAT |
|
| 161 |
GTTCTCGGGC |
TTCAACGCAG |
ACTACGAGGC |
GTCATCCTCC |
CGCTGCAGCA |
GCGCGTCCCC |
GGCCGGGGAT |
AGCCTCTCTT |
|
| 241 |
ACTACCACTC |
ACCCGCAGAC |
TCCTTCTCCA |
GCATGGGCTC |
GCCTGTCAAC |
GCGCAGGACT |
TCTGCACGGA |
CCTGGCCGTC |
|
| 321 |
TCCAGTGCCA |
ACTTCATTCC |
CACGGTCACT |
GCCATCTCGA |
CCAGTCCGGA |
CCTGCAGTGG |
CTGGTGCAGC |
CCGCCCTCGT |
|
| 401 |
CTCCTCTGTG |
GCCCCATCGC |
AGACCAGAGC |
CCCTCACCCT |
TTCGGAGTCC |
CCGCCCCCTC |
CGCTGGGGCT |
TACTCCAGGG |
|
| 481 |
CTGGCGTTGT |
GAAGACCATG |
ACAGGAGGCC |
GAGCGCAGAG |
CATTGGCAGG |
AGGGGCAAGG |
TGGAACAGTT |
ATCTCCAGAA |
|
| 561 |
GAAGAAGAGA |
AAAGGAGAAT |
CCGAAGGGAA |
AGGAATAAGA |
TGGCTGCAGC |
CAAATGCCGC |
AACCGGAGGA |
GGGAGCTGAC |
|
| 641 |
TGATACACTC |
CAAGCGGAGA |
CAGACCAACT |
AGAAGATGAG |
AAGTCTGCTT |
TGCAGACCGA |
GATTGCCAAC |
CTGCTGAAGG |
|
| 721 |
AGAAGGAAAA |
ACTAGAGTTC |
ATCCTGGCAG |
CTCACCGACC |
TGCCTGCAAG |
ATCCCTGATG |
ACCTGGGCTT |
CCCAGAAGAG |
|
| 801 |
ATGTCTGTGG |
CTTCCCTTGA |
TCTGACTGGG |
GGCCTGCCAG |
AGGTTGCCAC |
CCCGGAGTCT |
GAGGAGGCCT |
TCACCCTGCC |
|
| 881 |
TCTCCTCAAT |
GACCCTGAGC |
CCAAGCCCTC |
AGTGGAACCT |
GTCAAGAGCA |
TCAGCAGCAT |
GGAGCTGAAG |
ACCGAGCCCT |
|
| 961 |
TTGATGACTT |
CCTGTTCCCA |
GCATCATCCA |
GGCCCAGTGG |
CTCTGAGACA |
GCCCGCTCCG |
TGCCAGACAT |
GGACCTATCT |
|
| 1041 |
GGGTCCTTCT |
ATGCAGCAGA |
CTGGGAGCCT |
CTGCACAGTG |
GCTCCCTGGG |
GATGGGGCCC |
ATGGCCACAG |
AGCTGGAGCC |
|
| 1121 |
CCTGTGCACT |
CCGGTGGTCA |
CCTGTACTCC |
CAGCTGCACT |
GCTTACACGT |
CTTCCTTCGT |
CTTCACCTAC |
CCCGAGGCTG |
|
| 1201 |
ACTCCTTCCC |
CAGCTGTGCA |
GCTGCCCACC |
GCAAGGGCAG |
CAGCAGCAAT |
GAGCCTTCCT |
CTGACTCGCT |
CAGCTCACCC |
|
| 1281 |
ACGCTGCTGG |
CCCTGTGAGG |
GGGCAGGGAA |
GGGGAGGCAG |
CCGGCACCCA |
CAAGTGCCAC |
TGCCCGAGCT |
GGTGCATTAC |
|
| 1361 |
AGAGAGGAGA |
AACACATCTT |
CCCTAGAGGG |
TTCCTGTAGA |
CCTAGGGAGG |
ACCTTATCTG |
TGCGTGAAAC |
ACACCAGGCT |
|
| 1441 |
GTGGGCCTCA |
AGGACTTGAA |
AGCATCCATG |
TGTGGACTCA |
AGTCCTTACC |
TCTTCCGGAG |
ATGTAGCAAA |
ACGCATGGAG |
|
| 1521 |
TGTGTATTGT |
TCCCAGTGAC |
ACTTCAGAGA |
GCTGGTAGTT |
AGTAGCATGT |
TGAGCCAGGC |
CTGGGTCTGT |
GTCTCTTTTC |
|
| 1601 |
TCTTTCTCCT |
TAGTCTTCTC |
ATAGCATTAA |
CTAATCTATT |
GGGTTCATTA |
TTGGAATTAA |
CCTGGTGCTG |
GATATTTTCA |
|
| 1681 |
AATTGTATCT |
AGTGCAGCTG |
ATTTTAACAA |
TAACTACTGT |
GTTCCTGGCA |
ATAGTGTGTT |
CTGATTAGAA |
ATGACCAATA |
|
| 1761 |
TTATACTAAG |
AAAAGATACG |
ACTTTATTTT |
CTGGTAGATA |
GAAATAAATA |
GCTATATCCA |
TGTACTGTAG |
TTTTTCTTCA |
|
| 1841 |
ACATCAATGT |
TCATTGTAAT |
GTTACTGATC |
ATGCATTGTT |
GAGGTGGTCT |
GAATGTTCTG |
ACATTAACAG |
TTTTCCATGA |
|
| 1921 |
AAACGTTTTA |
TTGTGTTTTT |
AATTTATTTA |
TTAAGATGGA |
TTCTCAGATA |
TTTATATTTT |
TATTTTATTT |
TTTTCTACCT |
|
| 2001 |
TGAGGTCTTT |
TGACATGTGG |
AAAGTGAATT |
TGAATGAAAA |
ATTTAAGCAT |
TGTTTGCTTA |
TTGTTCCAAG |
ACATTGTCAA |
|
| 2081 |
TAAA |
|
|
|
|
|
|
|
|
|
|
|
|
>gi|6552332|ref|NM_005252.2|V-fos FBJ murine osteosarcoma viral oncogene homolog (FOS)
AACCGCATCTGCAGCGAGCAACTGAGAAGCCAAGACTGAGCCGGCGGCCGCGGCGCAGCGAACGAGCAGTGACCGTGCTC
CTACCCAGCTCTGCTTCACAGCGCCCACCTGTCTCCGCCCCTCGGCCCCTCGCCCGGCTTTGCCTAACCGCCACGATGAT
GTTCTCGGGCTTCAACGCAGACTACGAGGCGTCATCCTCCCGCTGCAGCAGCGCGTCCCCGGCCGGGGATAGCCTCTCTT
ACTACCACTCACCCGCAGACTCCTTCTCCAGCATGGGCTCGCCTGTCAACGCGCAGGACTTCTGCACGGACCTGGCCGTC
TCCAGTGCCAACTTCATTCCCACGGTCACTGCCATCTCGACCAGTCCGGACCTGCAGTGGCTGGTGCAGCCCGCCCTCGT
CTCCTCTGTGGCCCCATCGCAGACCAGAGCCCCTCACCCTTTCGGAGTCCCCGCCCCCTCCGCTGGGGCTTACTCCAGGG
CTGGCGTTGTGAAGACCATGACAGGAGGCCGAGCGCAGAGCATTGGCAGGAGGGGCAAGGTGGAACAGTTATCTCCAGAA
GAAGAAGAGAAAAGGAGAATCCGAAGGGAAAGGAATAAGATGGCTGCAGCCAAATGCCGCAACCGGAGGAGGGAGCTGAC
TGATACACTCCAAGCGGAGACAGACCAACTAGAAGATGAGAAGTCTGCTTTGCAGACCGAGATTGCCAACCTGCTGAAGG
AGAAGGAAAAACTAGAGTTCATCCTGGCAGCTCACCGACCTGCCTGCAAGATCCCTGATGACCTGGGCTTCCCAGAAGAG
ATGTCTGTGGCTTCCCTTGATCTGACTGGGGGCCTGCCAGAGGTTGCCACCCCGGAGTCTGAGGAGGCCTTCACCCTGCC
TCTCCTCAATGACCCTGAGCCCAAGCCCTCAGTGGAACCTGTCAAGAGCATCAGCAGCATGGAGCTGAAGACCGAGCCCT
TTGATGACTTCCTGTTCCCAGCATCATCCAGGCCCAGTGGCTCTGAGACAGCCCGCTCCGTGCCAGACATGGACCTATCT
GGGTCCTTCTATGCAGCAGACTGGGAGCCTCTGCACAGTGGCTCCCTGGGGATGGGGCCCATGGCCACAGAGCTGGAGCC
CCTGTGCACTCCGGTGGTCACCTGTACTCCCAGCTGCACTGCTTACACGTCTTCCTTCGTCTTCACCTACCCCGAGGCTG
ACTCCTTCCCCAGCTGTGCAGCTGCCCACCGCAAGGGCAGCAGCAGCAATGAGCCTTCCTCTGACTCGCTCAGCTCACCC
ACGCTGCTGGCCCTGTGAGGGGGCAGGGAAGGGGAGGCAGCCGGCACCCACAAGTGCCACTGCCCGAGCTGGTGCATTAC
AGAGAGGAGAAACACATCTTCCCTAGAGGGTTCCTGTAGACCTAGGGAGGACCTTATCTGTGCGTGAAACACACCAGGCT
GTGGGCCTCAAGGACTTGAAAGCATCCATGTGTGGACTCAAGTCCTTACCTCTTCCGGAGATGTAGCAAAACGCATGGAG
TGTGTATTGTTCCCAGTGACACTTCAGAGAGCTGGTAGTTAGTAGCATGTTGAGCCAGGCCTGGGTCTGTGTCTCTTTTC
TCTTTCTCCTTAGTCTTCTCATAGCATTAACTAATCTATTGGGTTCATTATTGGAATTAACCTGGTGCTGGATATTTTCA
AATTGTATCTAGTGCAGCTGATTTTAACAATAACTACTGTGTTCCTGGCAATAGTGTGTTCTGATTAGAAATGACCAATA
TTATACTAAGAAAAGATACGACTTTATTTTCTGGTAGATAGAAATAAATAGCTATATCCATGTACTGTAGTTTTTCTTCA
ACATCAATGTTCATTGTAATGTTACTGATCATGCATTGTTGAGGTGGTCTGAATGTTCTGACATTAACAGTTTTCCATGA
AAACGTTTTATTGTGTTTTTAATTTATTTATTAAGATGGATTCTCAGATATTTATATTTTTATTTTATTTTTTTCTACCT
TGAGGTCTTTTGACATGTGGAAAGTGAATTTGAATGAAAAATTTAAGCATTGTTTGCTTATTGTTCCAAGACATTGTCAA
TAAA
|
|
|
| |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Exon number |
1
|
| Length |
296 nt
|
| Location |
Chromosome 14 (NC_000014.8) : 75745530...75745825 (+)
|
| Is part of |
FOS, mRNA isoform 1
(NM_005252.2)
|
| Sequence |
Show
|
|
AACCGCATCTGCAGCGAGCAACTGAGAAGCCAAGACTGAGCCGGCGGCCGCGGCGCAGCGAACGAGCAGTGACCGTGCTC
CTACCCAGCTCTGCTTCACAGCGCCCACCTGTCTCCGCCCCTCGGCCCCTCGCCCGGCTTTGCCTAACCGCCACGATGAT
GTTCTCGGGCTTCAACGCAGACTACGAGGCGTCATCCTCCCGCTGCAGCAGCGCGTCCCCGGCCGGGGATAGCCTCTCTT
ACTACCACTCACCCGCAGACTCCTTCTCCAGCATGGGCTCGCCTGTCAACGCGCAG
|
|
|
|
|
|
|
|
|
|
|
|
|
| Exon number |
2
|
| Length |
252 nt
|
| Location |
Chromosome 14 (NC_000014.8) : 75746579...75746830 (+)
|
| Is part of |
FOS, mRNA isoform 1
(NM_005252.2)
|
| Sequence |
Show
|
|
GACTTCTGCACGGACCTGGCCGTCTCCAGTGCCAACTTCATTCCCACGGTCACTGCCATCTCGACCAGTCCGGACCTGCA
GTGGCTGGTGCAGCCCGCCCTCGTCTCCTCTGTGGCCCCATCGCAGACCAGAGCCCCTCACCCTTTCGGAGTCCCCGCCC
CCTCCGCTGGGGCTTACTCCAGGGCTGGCGTTGTGAAGACCATGACAGGAGGCCGAGCGCAGAGCATTGGCAGGAGGGGC
AAGGTGGAACAG
|
|
|
|
|
|
|
|
|
|
|
|
|
| Exon number |
3
|
| Length |
108 nt
|
| Location |
Chromosome 14 (NC_000014.8) : 75747262...75747369 (+)
|
| Is part of |
FOS, mRNA isoform 1
(NM_005252.2)
|
| Sequence |
Show
|
|
TTATCTCCAGAAGAAGAAGAGAAAAGGAGAATCCGAAGGGAAAGGAATAAGATGGCTGCAGCCAAATGCCGCAACCGGAG
GAGGGAGCTGACTGATACACTCCAAGCG
|
|
|
|
|
|
|
|
|
|
|
|
|
| Exon number |
4
|
| Length |
1428 nt
|
| Location |
Chromosome 14 (NC_000014.8) : 75747485...75748912 (+)
|
| Is part of |
FOS, mRNA isoform 1
(NM_005252.2)
|
| Sequence |
Show
|
|
GAGACAGACCAACTAGAAGATGAGAAGTCTGCTTTGCAGACCGAGATTGCCAACCTGCTGAAGGAGAAGGAAAAACTAGA
GTTCATCCTGGCAGCTCACCGACCTGCCTGCAAGATCCCTGATGACCTGGGCTTCCCAGAAGAGATGTCTGTGGCTTCCC
TTGATCTGACTGGGGGCCTGCCAGAGGTTGCCACCCCGGAGTCTGAGGAGGCCTTCACCCTGCCTCTCCTCAATGACCCT
GAGCCCAAGCCCTCAGTGGAACCTGTCAAGAGCATCAGCAGCATGGAGCTGAAGACCGAGCCCTTTGATGACTTCCTGTT
CCCAGCATCATCCAGGCCCAGTGGCTCTGAGACAGCCCGCTCCGTGCCAGACATGGACCTATCTGGGTCCTTCTATGCAG
CAGACTGGGAGCCTCTGCACAGTGGCTCCCTGGGGATGGGGCCCATGGCCACAGAGCTGGAGCCCCTGTGCACTCCGGTG
GTCACCTGTACTCCCAGCTGCACTGCTTACACGTCTTCCTTCGTCTTCACCTACCCCGAGGCTGACTCCTTCCCCAGCTG
TGCAGCTGCCCACCGCAAGGGCAGCAGCAGCAATGAGCCTTCCTCTGACTCGCTCAGCTCACCCACGCTGCTGGCCCTGT
GAGGGGGCAGGGAAGGGGAGGCAGCCGGCACCCACAAGTGCCACTGCCCGAGCTGGTGCATTACAGAGAGGAGAAACACA
TCTTCCCTAGAGGGTTCCTGTAGACCTAGGGAGGACCTTATCTGTGCGTGAAACACACCAGGCTGTGGGCCTCAAGGACT
TGAAAGCATCCATGTGTGGACTCAAGTCCTTACCTCTTCCGGAGATGTAGCAAAACGCATGGAGTGTGTATTGTTCCCAG
TGACACTTCAGAGAGCTGGTAGTTAGTAGCATGTTGAGCCAGGCCTGGGTCTGTGTCTCTTTTCTCTTTCTCCTTAGTCT
TCTCATAGCATTAACTAATCTATTGGGTTCATTATTGGAATTAACCTGGTGCTGGATATTTTCAAATTGTATCTAGTGCA
GCTGATTTTAACAATAACTACTGTGTTCCTGGCAATAGTGTGTTCTGATTAGAAATGACCAATATTATACTAAGAAAAGA
TACGACTTTATTTTCTGGTAGATAGAAATAAATAGCTATATCCATGTACTGTAGTTTTTCTTCAACATCAATGTTCATTG
TAATGTTACTGATCATGCATTGTTGAGGTGGTCTGAATGTTCTGACATTAACAGTTTTCCATGAAAACGTTTTATTGTGT
TTTTAATTTATTTATTAAGATGGATTCTCAGATATTTATATTTTTATTTTATTTTTTTCTACCTTGAGGTCTTTTGACAT
GTGGAAAGTGAATTTGAATGAAAAATTTAAGCATTGTTTGCTTATTGTTCCAAGACATTGTCAATAAA
|
|
|
|
|
|
|
|
|
|
|
|
|
| Primary source |
Uniprot : P01100
|
| Name |
Proto-oncogene c-Fos
|
| Alternative name(s) |
Cellular oncogene fos
G0/G1 switch regulatory protein 7
|
| Synonym(s) |
|
| Organism |
Homo sapiens
|
| Length |
380 aa
|
| Protein existence |
---
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
General annotation (Comments)
|
top
|
|
|
|
|
|
|
|
Function
|
Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.
|
|
Ptm
|
Phosphorylated in the C-terminal upon stimulation by nerve growth factor (NGF) and epidermal growth factor (EGF). Phosphorylated, in vitro, by MAPK and RSK1. Phosphorylation on both Ser-362 and Ser-374 by MAPK1/2 and RSK1/2 leads to protein stabilization with phosphorylation on Ser-374 being the major site for protein stabilization on NGF stimulation. Phosphorylation on Ser-362 and Ser-374 primes further phosphorylations on Thr-325 and Thr-331 through promoting docking of MAPK to the DEF domain. Phosphorylation on Thr-232, induced by HA-RAS, activates the transcriptional activity and antagonizes sumoylation. Phosphorylation on Ser-362 by RSK2 in osteoblasts contributes to osteoblast transformation (By similarity).
Constitutively sumoylated by SUMO1, SUMO2 and SUMO3. Desumoylated by SENP2. Sumoylation requires heterodimerization with JUN and is enhanced by mitogen stimulation. Sumoylation inhibits the AP-1 transcriptional activity and is, itself, inhibited by Ras-activated phosphorylation on Thr-232.
|
|
Similarity
|
Belongs to the bZIP family. Fos subfamily.
Contains 1 bZIP domain.
|
|
Subcellular location
|
Nucleus.
|
|
Subunit
|
Heterodimer with JUN. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA. Interacts with MAFB (By similarity).
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Biological process
|
DNA methylation [GO:0006306]
inflammatory response [GO:0006954]
transforming growth factor beta receptor signaling pathway [GO:0007179]
cellular response to reactive oxygen species [GO:0034614]
SMAD protein signal transduction [GO:0060395]
|
|
Molecular function
|
transcription factor activity [GO:0003700]
specific RNA polymerase II transcription factor activity [GO:0003704]
promoter binding [GO:0010843]
protein dimerization activity [GO:0046983]
R-SMAD binding [GO:0070412]
|
|
|
|
|
|
|
|
|
|
|
|
|
|
With
|
Uniprot accession
|
IntAct
|
|
PPP1R12A
|
O14974
|
EBI-852851,EBI-351726
|
|
RRP12
|
Q5JTH9
|
EBI-852851,EBI-310743
|
|
TMSB10
|
P63313
|
EBI-852851,EBI-2688673
|
|
SLC4A10
|
Q6U841
|
EBI-852851,EBI-2679540
|
|
LRRC59
|
Q96AG4
|
EBI-852851,EBI-358888
|
|
ESF1
|
Q9H501
|
EBI-852851,EBI-2681618
|
|
MAP1B
|
P46821
|
EBI-852851,EBI-764611
|
|
MATR3
|
P43243
|
EBI-852851,EBI-352602
|
|
NCL
|
P19338
|
EBI-852851,EBI-346967
|
|
SF3A3
|
Q12874
|
EBI-852851,EBI-1051880
|
|
GNL2
|
Q13823
|
EBI-852851,EBI-1043365
|
|
PPIG
|
Q13427
|
EBI-852851,EBI-396072
|
|
RPS17
|
P08708
|
EBI-852851,EBI-358255
|
|
???
|
Q7CHQ0
|
EBI-852851,EBI-2841736
|
|
RPS11
|
P62280
|
EBI-852851,EBI-1047710
|
|
MAN1A2
|
O60476
|
EBI-852851,EBI-2681868
|
|
YWHAB
|
P31946
|
EBI-852851,EBI-359815
|
|
ATP5I
|
P56385
|
EBI-852851,EBI-2270000
|
|
CABP1
|
Q9NZU7
|
EBI-852851,EBI-907894
|
|
EP400
|
Q96L91
|
EBI-852851,EBI-399163
|
|
NPIP
|
Q9UND3
|
EBI-852851,EBI-2692961
|
|
APP
|
P05067
|
EBI-852851,EBI-77613
|
|
TLN2
|
Q9Y4G6
|
EBI-852851,EBI-1220811
|
|
PKNOX2
|
Q96KN3
|
EBI-852851,EBI-2692890
|
|
PKP2
|
Q99959
|
EBI-852851,EBI-702235
|
|
PNN
|
Q9H307
|
EBI-852851,EBI-681904
|
|
ZNF133
|
P52736
|
EBI-852851,EBI-2687350
|
|
APLP1
|
P51693
|
EBI-852851,EBI-74648
|
|
FAM50A
|
Q14320
|
EBI-852851,EBI-2687434
|
|
JUN
|
P05412
|
EBI-852851,EBI-852823
|
|
RGS7
|
P49802
|
EBI-852851,EBI-1754797
|
|
EDF1
|
O60869-1
|
EBI-852851,
|
|
USP16
|
Q9Y5T5
|
EBI-852851,EBI-2513357
|
|
SERBP1
|
Q8NC51
|
EBI-852851,EBI-523558
|
|
RBM6
|
P78332
|
EBI-852851,EBI-2692323
|
|
ATF2
|
P15336
|
EBI-852851,EBI-1170906
|
|
|
|
|
|
|
|
Alternative product(s)
|
top
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Feature key |
Position
|
Length
|
Description
|
Feature identifier
|
Region
|
|
|
|
|
|
Dna binding
|
139 - 160
|
22
|
Basic motif
|
P01100-DNA_BIND-139
|
|
Domain
|
165 - 193
|
29
|
Leucine-zipper
|
P01100-DOMAIN-165
|
Amino acid modifications
|
|
|
|
|
|
Crosslink
|
113 - 113
|
1
|
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
|
P01100-CROSSLNK-113
|
|
Crosslink
|
265 - 265
|
1
|
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) (By similarity)
|
P01100-CROSSLNK-265
|
|
Modified residue
|
232 - 232
|
1
|
Phosphothreonine (By similarity)
|
P01100-MOD_RES-232
|
|
Modified residue
|
325 - 325
|
1
|
Phosphothreonine (By similarity)
|
P01100-MOD_RES-325
|
|
Modified residue
|
331 - 331
|
1
|
Phosphothreonine (By similarity)
|
P01100-MOD_RES-331
|
|
Modified residue
|
362 - 362
|
1
|
Phosphoserine; by MAPK and RPS6KA3
|
P01100-MOD_RES-362
|
|
Modified residue
|
374 - 374
|
1
|
Phosphoserine; by MAPK
|
P01100-MOD_RES-374
|
Experimental info
|
|
|
|
|
|
Mutagenesis
|
128 - 128
|
1
|
K->R: No change in sumoylation
|
P01100-MUTAGEN-128
|
|
Mutagenesis
|
192 - 192
|
1
|
K->R: No change in sumoylation
|
P01100-MUTAGEN-192
|
|
Mutagenesis
|
232 - 232
|
1
|
T->D: Decreased sumoylation levels
|
P01100-MUTAGEN-232
|
|
Mutagenesis
|
265 - 265
|
1
|
K->R: Abolishes sumoylation. No change in nuclear location nor on protein stability. Increased AP1 transactivation activity when heterodimerized with cJUN
|
P01100-MUTAGEN-265
|
|
Mutagenesis
|
325 - 325
|
1
|
T->D: No change in sumoylation levels
|
P01100-MUTAGEN-325
|
|
Mutagenesis
|
331 - 331
|
1
|
T->D: No change in sumoylation levels
|
P01100-MUTAGEN-331
|
|
Mutagenesis
|
362 - 362
|
1
|
S->D: Increased protein stability. Increased MOS/MAPK-mediated transforming ability and no change in sumoylation levels; when associated with D-374
|
P01100-MUTAGEN-362
|
|
Mutagenesis
|
374 - 374
|
1
|
S->D: Increased protein stability. Increased MOS/MAPK-mediated transforming ability and no change in sumoylation levels; when associated with D-362
|
P01100-MUTAGEN-374
|
|
|
|
|
|
|
|
|
|
|
|
|
| 1 |
MMFSGFNADY |
EASSSRCSSA |
SPAGDSLSYY |
HSPADSFSSM |
GSPVNAQDFC |
TDLAVSSANF |
IPTVTAISTS |
PDLQWLVQPA |
|
| 81 |
LVSSVAPSQT |
RAPHPFGVPA |
PSAGAYSRAG |
VVKTMTGGRA |
QSIGRRGKVE |
QLSPEEEEKR |
RIRRERNKMA |
AAKCRNRRRE |
|
| 161 |
LTDTLQAETD |
QLEDEKSALQ |
TEIANLLKEK |
EKLEFILAAH |
RPACKIPDDL |
GFPEEMSVAS |
LDLTGGLPEV |
ATPESEEAFT |
|
| 241 |
LPLLNDPEPK |
PSVEPVKSIS |
SMELKTEPFD |
DFLFPASSRP |
SGSETARSVP |
DMDLSGSFYA |
ADWEPLHSGS |
LGMGPMATEL |
|
| 321 |
EPLCTPVVTC |
TPSCTAYTSS |
FVFTYPEADS |
FPSCAAAHRK |
GSSSNEPSSD |
SLSSPTLLAL |
|
|
|
|
|
|
|
|
|
|
|
|
>sp|P01100|FOS_human Proto-oncogene c-Fos
MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANFIPTVTAISTSPDLQWLVQPA
LVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRAQSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRE
LTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEVATPESEEAFT
LPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRPSGSETARSVPDMDLSGSFYAADWEPLHSGSLGMGPMATEL
EPLCTPVVTCTPSCTAYTSSFVFTYPEADSFPSCAAAHRKGSSSNEPSSDSLSSPTLLAL
|
|
|
| |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Primary source |
Uniprot : Q6FG41
|
| Name |
FOS protein [submitted name]
|
| Alternative name(s) |
V-fos FBJ murine osteosarcoma viral oncogene homolog, isoform CRA_a [submitted name]
cDNA FLJ76842, highly similar to Homo sapiens v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS), mRNA [submitted name]
|
| Synonym(s) |
|
| Organism |
Homo sapiens
|
| Length |
380 aa
|
| Protein existence |
---
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
General annotation (Comments)
|
top
|
|
|
|
|
|
|
|
Similarity
|
Belongs to the bZIP family.
Contains 1 bZIP domain.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Molecular function
|
sequence-specific DNA binding [GO:0043565]
|
|
|
|
|
|
|
|
|
|
|
|
|
|
With
|
Uniprot accession
|
IntAct
|
|
|
|
|
|
|
|
Alternative product(s)
|
top
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Feature key |
Position
|
Length
|
Description
|
Feature identifier
|
|
|
|
|
|
|
|
|
|
|
|
|
| 1 |
MMFSGFNADY |
EASSSRCSSA |
SPAGDSLSYY |
HSPADSFSSM |
GSPVNAQDFC |
TDLAVSSANF |
IPTVTAISTS |
PDLQWLVQPA |
|
| 81 |
LVSSVAPSQT |
RAPHPFGVPA |
PSAGAYSRAG |
VVKTMTGGRA |
QSIGRRGKVE |
QLSPEEEEKR |
RIRRERNKMA |
AAKCRNRRRE |
|
| 161 |
LTDTLQAETD |
QLEDEKSALQ |
TEIANLLKEK |
EKLEFILAAH |
RPACKIPDDL |
GFPEEMSVAS |
LDLTGGLPEV |
ATPESEEAFT |
|
| 241 |
LPLLNDPEPK |
PSVEPVKSIS |
SMELKTEPFD |
DFLFPASSRP |
SGSETARSVP |
DMDLSGSFYA |
ADWEPLHSGS |
LGMGPMATEL |
|
| 321 |
EPLCTPVVTC |
TPSCTAYTSS |
FVFTYPEADS |
FPSCAAAHRK |
GSSSNEPSSD |
SLSSPTLLAL |
|
|
|
|
|
|
|
|
|
|
|
|
>sp|Q6FG41|Q6FG41_human FOS protein [submitted name]
MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANFIPTVTAISTSPDLQWLVQPA
LVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRAQSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRE
LTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEVATPESEEAFT
LPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRPSGSETARSVPDMDLSGSFYAADWEPLHSGSLGMGPMATEL
EPLCTPVVTCTPSCTAYTSSFVFTYPEADSFPSCAAAHRKGSSSNEPSSDSLSSPTLLAL
|
|
|
| |
|
|
|
|
|
|
