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(CDKN1A) cyclin-dependent kinase inhibitor 1A (p21, Cip1) [Homo sapiens]

Gene

Transcript(s)

Exon(s)

Protein(s)

Gene

Accession	37723
Official symbol	CDKN1A
Official name	cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Gene type	protein-coding
Organism	Homo sapiens
Location	chromosome 6 (NC_000006.10) : 36754465...36763088 (+)
Map	6p21.2
Length	8623 nt

Alternative name(s) and Synynom(s) top

Synonyms	p21CIP1; WAF1; SDI1; P21; MDA-6; CIP1; CDKN1; CAP20
Names	wild-type p53-activated fragment 1 melanoma differentiation associated protein 6 cyclin-dependent kinase inhibitor 1A OTTHUMP00000016298 DNA synthesis inhibitor CDK-interaction protein 1

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Ensembl	ENSG00000124762
GeneID	1026
HGNC	1784
HPRD	00298

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Summary

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported.

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