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Alternative name(s) and Synynom(s)
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| Synonyms |
AUTL2; APG4A
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| Names |
APG4 autophagy 4 homolog A (S. cerevisiae)
AUT-like 2, cysteine endopeptidase (S. cerevisiae)
autophagy-related cysteine endopeptidase 2
autophagin 2
OTTHUMP00000062893
OTTHUMP00000023822
AUT-like 2, cysteine endopeptidase
APG4 autophagy 4 homolog A
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External Links
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Comment
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| Summary |
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified.
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Bibliography
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Related Articles in PubMed
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Homologuous Genes
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Pathways
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Sequence
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