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(ATF4) activating transcription factor 4 (tax-responsive enhancer element B67) [Homo sapiens]

Gene

Transcript(s)

Exon(s)

Protein(s)

Gene

Accession	35312
Official symbol	ATF4
Official name	activating transcription factor 4 (tax-responsive enhancer element B67)
Gene type	protein-coding
Organism	Homo sapiens
Location	chromosome 22 (NC_000022.9) : 38246515...38248638 (+)
Map	22q13.1
Length	2123 nt

Alternative name(s) and Synynom(s) top

Synonyms	TXREB; TAXREB67; CREB2; CREB-2
Names	cAMP response element-binding protein 2 activating transcription factor 4

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Ensembl	ENSG00000128272
GeneID	468
HGNC	786
HPRD	06817

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Summary

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication. [provided by RefSeq].

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