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(BIRC5) baculoviral IAP repeat-containing 5 [Homo sapiens]

Gene

Transcript(s)

Exon(s)

Protein(s)

Gene

Accession	32682
Official symbol	BIRC5
Official name	baculoviral IAP repeat-containing 5
Gene type	protein-coding
Organism	Homo sapiens
Location	chromosome 17 (NC_000017.9) : 73721872...73733312 (+)
Map	17q25
Length	11440 nt

Alternative name(s) and Synynom(s) top

Synonyms	EPR-1; API4
Names	survivin variant 3 alpha baculoviral IAP repeat-containing protein 5 apoptosis inhibitor 4

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Ensembl	ENSG00000089685
GeneID	332
HGNC	593
HPRD	04520

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Summary

This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors yet low in adult tissues. Antisense transcripts are involved in the regulation of this gene's expression. At least four transcript variants encoding distinct isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq].

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