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(AKT1) v-akt murine thymoma viral oncogene homolog 1 [Homo sapiens]

Gene

Transcript(s)

Exon(s)

Protein(s)

Gene

Accession	30364
Official symbol	AKT1
Official name	v-akt murine thymoma viral oncogene homolog 1
Gene type	protein-coding
Organism	Homo sapiens
Location	chromosome 14 (NC_000014.7) : 104306731...104333126 (-)
Map	14q32.32\|14q32.32
Length	26395 nt

Alternative name(s) and Synynom(s) top

Synonyms	RAC-ALPHA; RAC; PRKBA; PKB-ALPHA; PKB; MGC99656; AKT
Names	rac protein kinase alpha protein kinase B murine thymoma viral (v-akt) oncogene homolog-1 RAC-alpha serine/threonine-protein kinase

External Links top

EC_number	2.7.1.37
Ensembl	ENSG00000142208
GeneID	207
HGNC	391
HPRD	01261

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Summary

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq].

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