(CDKN1B) cyclin-dependent kinase inhibitor 1B (p27, Kip1) [Homo sapiens]
Gene
Transcript(s)
Exon(s)
Protein(s)
Gene
 Accession  29729
 Official symbol  CDKN1B
 Official name  cyclin-dependent kinase inhibitor 1B (p27, Kip1)
 Gene type  protein-coding
 Organism  Homo sapiens
 Location  chromosome 12 (NC_000012.10) : 12761576...12766571  (+)
 Map  12p13.1-p12
 Length  4995  nt
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Alternative name(s) and Synynom(s) top
Synonyms P27KIP1; MEN4; MEN1B; KIP1; CDKN4
Names cyclin-dependent kinase inhibitor 1B
External Links top
Ensembl ENSG00000111276
GeneID 1027
HGNC 1785
HPRD 02867
Comment top
Summary This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq].
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