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(CASP4) caspase 4, apoptosis-related cysteine peptidase [Homo sapiens]

Gene

Transcript(s)

Exon(s)

Protein(s)

Gene

Accession	29071
Official symbol	CASP4
Official name	caspase 4, apoptosis-related cysteine peptidase
Gene type	protein-coding
Organism	Homo sapiens
Location	chromosome 11 (NC_000011.8) : 104318804...104344536 (-)
Map	11q22.2-q22.3
Length	25732 nt

Alternative name(s) and Synynom(s) top

Synonyms	TX; Mih1/TX; ICH-2; ICEREL-II; ICE(rel)II
Names	caspase 4, apoptosis-related cysteine protease caspase 4 apoptotic cysteine protease Mih1/TX

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Ensembl	ENSG00000196954
GeneID	837
HGNC	1505
HPRD	04047

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Summary

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq].

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