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(CASP1) caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) [Homo sapiens]

Gene

Transcript(s)

Exon(s)

Protein(s)

Gene

Accession	29013
Official symbol	CASP1
Official name	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
Gene type	protein-coding
Organism	Homo sapiens
Location	chromosome 11 (NC_000011.8) : 104401445...104411068 (-)
Map	11q23
Length	9623 nt

Alternative name(s) and Synynom(s) top

Synonyms	P45; IL1BC; ICE
Names	interleukin 1-beta convertase interleukin 1-B converting enzyme caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase) caspase 1 IL1B-convertase CASP1 nirs variant 1

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Ensembl	ENSG00000137752
GeneID	834
HGNC	1499
HPRD	00977

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Summary

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. [provided by RefSeq].

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