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(BAG3) BCL2-associated athanogene 3 [Homo sapiens]

Gene

Transcript(s)

Exon(s)

Protein(s)

Gene

Accession	28453
Official symbol	BAG3
Official name	BCL2-associated athanogene 3
Gene type	protein-coding
Organism	Homo sapiens
Location	chromosome 10 (NC_000010.9) : 121400872...121427322 (+)
Map	10q25.2-q26.2
Length	26450 nt

Alternative name(s) and Synynom(s) top

Synonyms	MGC104307; CAIR-1; BIS; BAG-3
Names	docking protein CAIR-1 OTTHUMP00000020599 Bcl-2-binding protein BCL2-binding athanogene 3 BAG-family molecular chaperone regulator-3

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Ensembl	ENSG00000151929
GeneID	9531
HGNC	939
HPRD	04860

Comment top

Summary

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq].

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