| (CASP3) caspase 3, apoptosis-related cysteine peptidase [Homo sapiens] |
|
|
|
|
|
|
|
|
Gene
Transcript(s)
Exon(s)
Protein(s)
|
|
|
Accession
|
25526
|
|
Official symbol
|
CASP3
|
|
Official name
|
caspase 3, apoptosis-related cysteine peptidase
|
|
Gene type
|
protein-coding
|
|
Organism
|
Homo sapiens
|
|
Location
|
chromosome 4 (NC_000004.10) : 185785844...185807624 (-)
|
|
Map
|
4q34
|
|
Length
|
21780 nt
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Alternative name(s) and Synynom(s)
top
|
|
|
|
|
|
| Synonyms |
apopain; Yama; SCA-1; CPP32B; CPP32
|
| Names |
procaspase3
cysteine protease CPP32
caspase 3, apoptosis-related cysteine protease
caspase 3
SREBP cleavage activity 1
PARP cleavage protease
OTTHUMP00000165054
|
|
|
|
|
|
|
External Links
top
|
|
|
|
|
|
|
|
|
|
|
|
Comment
top
|
|
|
|
|
|
| Summary |
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq].
|
|
|
|
|
|
|
Bibliography
top
|
|
|
|
|
|
Related Articles in PubMed
|
|
|
|
|
|
Genome Browser
top
|
|
|
|
|
|
Go to our internal gbrowse 
|
|
|
|
|
|
Genome Context
top
|
|
|
|
|
|
Go to ensembl 
|
|
|
|
|
|
Homologuous Genes
top
|
|
|
|
|
|
|
|
|
|
|
|
Pathways
top
|
|
|
|
|
|
|
|
|
|
|
|
Sequence
top
|
|
|
|
|
|
Get sequence
|
|
|
|
|
|
