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(CASP8) caspase 8, apoptosis-related cysteine peptidase [Homo sapiens]

Gene

Transcript(s)

Exon(s)

Protein(s)

Gene

Accession	23696
Official symbol	CASP8
Official name	caspase 8, apoptosis-related cysteine peptidase
Gene type	protein-coding
Organism	Homo sapiens
Location	chromosome 2 (NC_000002.10) : 201806411...201860680 (+)
Map	2q33-q34
Length	54269 nt

Alternative name(s) and Synynom(s) top

Synonyms	MGC78473; MCH5; MACH; FLJ17672; FLICE; CAP4; ALPS2B
Names	procaspase-8 cysteine protease caspase 8, apoptosis-related cysteine protease caspase 8 OTTHUMP00000163720 OTTHUMP00000163719 OTTHUMP00000163718 Mch5 isoform alpha MACH-beta-1/2/3/4 protein MACH-alpha-1/2/3 protein FADD-homologous ICE/CED-3-like protease

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Ensembl	ENSG00000064012
GeneID	841
HGNC	1509
HPRD	03459

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Summary

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq].

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