Look for Gene | Autophagy database

(ARNT) aryl hydrocarbon receptor nuclear translocator [Homo sapiens]

Gene

Transcript(s)

Exon(s)

Protein(s)

Gene

Accession	22806
Official symbol	ARNT
Official name	aryl hydrocarbon receptor nuclear translocator
Gene type	protein-coding
Organism	Homo sapiens
Location	chromosome 1 (NC_000001.9) : 149048810...149115811 (-)
Map	1q21
Length	67001 nt

Alternative name(s) and Synynom(s) top

Synonyms	bHLHe2; TANGO; HIF1BETA; HIF1B; HIF-1beta
Names	hypoxia-inducible factor 1, beta subunit dioxin receptor, nuclear translocator OTTHUMP00000032943

External Links top

Ensembl	ENSG00000143437
GeneID	405
HGNC	700
HPRD	00524

Comment top

Summary

The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Three alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq].

Bibliography top